2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor
  5. P2Y14 Receptor Isoform
  6. P2Y14 Receptor Antagonist

P2Y14 Receptor Antagonist

P2Y14 Receptor Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-161727
    P2Y14R antagonist 1
    		Antagonist
    P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis.
  • HY-161343
    HDL-16
    		Antagonist
    HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function.
  • HY-162661
    P2Y14R antagonist 2
    		Antagonist
    P2Y14R antagonist 2 (compound 39) is a potent, selective and orally active P2Y14R antagonist with an IC50 value of 0.40 nM. P2Y14R antagonist 2 shows anti-inflammatory activity. P2Y14R antagonist 2 has the potential for the research of colitis.